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Gene Therapy and Regulation

Volume 2, No. 2, pp. 91--176, 2003

Editorial --- Stem cell gene therapy: breakthrough culminating in combination of ex vivo protocols with transient topical gene therapy
R. Bertolotti 91

Site-specific integration: optimizing long-term safety and transgene expression

Phage C31 integrase-mediated site-specific integration for gene therapy
E. C. Olivares and M. P. Calos 103

The pros and cons of using the mechanism of AAV site-specific recombination in gene delivery
N. A. Allen and R. J. Samulski 121

Targeted cell delivery and tight cell-specific transgene regulation

Alternative capsid strategies for targeting recombinant AAV gene therapy
S. A. Loiler and T. R. Flotte 139

Globin gene transfer: a paradigm for transgene regulation and vector safety
S. Rivella, L. Lisowski and M. Sadelain 149