Editors: H. Yasuhara, S.H. Parvez, K. Oguchi, M. Sandler andT. Nagatsu
Monoamine oxidase (MAO), a mitochondrial enzyme whichmetabolizes monoamines in both the central nervous system and peripheraltissues, plays an important role in the regulation of neuronalactivities by controlling the concentrations of monoamines. During thepast three decades the enzymological properties of MAO have been studiedextensively. The most exciting and important advances in these studieshave been the determination of the nucleotide sequence coding two formsof human MAO (MAO-A and MAO-B), and the involvement of MAO in potentdopaminergic neurotoxicity of MPTP, which had led to the accelerationof aetiological studies of Parkinson's disease. Other aspects of MAOstudies have been the application of selective and safe MAO inhibitorsin the treatment of depression and Parkinson's disease as well as thecorrelation between MAO and several psychiatric and neurodegenerativedisorders.
This book contains up-to-date studies of both basic research andapplications in the above mentioned areas of MAO studies. The book willbe of interest to researchers in the field of neuroscience,neurochemistry, neuropharmacology and clinical pharmacology, in bothacademic and industrial spheres.
1993; viii+232 pages ISBN 90-6764-146-4 Price (all prices are subject to change without notice): EUR 127/US$ 182
